Manifestation of neuronal ceroid lipofuscinosis in Australian Merino sheep: Observations on altered behaviour and growth
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چکیده
منابع مشابه
Neuronal Ceroid Lipofuscinosis in Australian Merino Sheep
The neuronal ceroid lipofuscinoses (NCLs) are a group of inherited neurodegenerative diseases characterised by the accumulation of autofluorescent lipopigment in a variety of tissues. At least six different forms of NCL occur in humans and the disease has been identified in various animal species, including sheep. Clinical features of NCL are dementia, loss of vision, motor disturbances, and pr...
متن کاملJuvenile-onset neuronal ceroid-lipofuscinosis in Rambouillet sheep.
Two, 8-month-old Rambouillet half-sister ewes with signs of visual loss and decreased mentation were examined. Ewe No. 1 was necropsied at 10 months of age, and after being held under observation for a further 6 months, ewe No. 2 was necropsied at 16 months of age. At that time, the ewe was blind and severely depressed. Both ewes had deposition of an autofluorescent lipopigment, identified as c...
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An 11-year-old girl with juvenile neuronal ceroid lipofuscinosis developed acute pancreatitis secondary to valproic acid treatment, which resolved after discontinuation of the medication and conservative treatment. To my knowledge, this is the first reported case of neuronal ceroid lipofuscinosis with valproate-associated pancreatitis. Children with neuronal ceroid lipofuscinosis may be suscept...
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A lysosomal storage disease with accumulation of periodic acid-Schiff- and Sudan black-positive autofluorescent granules in neurons occurred in one 5 1/2- and one 7-year-old dachshund. Ultrastructurally, the storage material consisted of membranous material arranged in stacks and fingerprint patterns. The disease was defined as ceroid-lipofuscinosis, and resembled a previously reported case in ...
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The neuronal ceroid-lipofuscinoses are a group of diseases characterized by progressive accumulation of autofluorescent lipopigments within neurons with associated neuronal damage." Variations of these diseases occur which include accumulations of lipopigments in viscera. The diseases long have been recognized in man where earlier studies of the pathogenesis suggested an increased rate of perox...
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ژورنال
عنوان ژورنال: Applied Animal Behaviour Science
سال: 2016
ISSN: 0168-1591
DOI: 10.1016/j.applanim.2015.11.012